ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and safety of rush immunotherapy (RIT) for patients with persistent allergic rhinitis (AR).</p><p><b>METHODS</b>In this study, a total number of thirty three (33) patients who suffered mite allergic rhinitis were included. These patients completed one year subcutaneous immunotherapy (SCIT). Using RIT, the patients underwent the incremental dose phase in a week instead of 15 weeks in a conventional treatment procedure. The symptom scores, visual analog scale (VAS), appropriate medication score, total blood serum IgE, dermatophagoides pteronyssinus specificity IgG4, mite allergy skin prick test (SPT), dermatophagoides farinae nasal provocation test (NPT) and the incidence of adverse reactions were used to evaluate the efficiency and safety of RIT.</p><p><b>RESULTS</b>After one year SCIT treatment, the symptom score and VAS scores were significantly decreased, the corresponding medication usage was significantly reduced (8.91 ± 1.84, 20.64 ± 6.99 vs. 4.97 ± 2.92, 11.94 ± 7.21, t value was 9.15, 7.11, both P < 0.001) and the cutaneous reactions to mite allergen were significantly decreased (P < 0.001) as well. However, dermatophagoides pteronyssinus-specific serum IgG4 increased significantly (Z = -4.517, P < 0.001). The concentration of dermatophagoides farinae nasal provocation test (NPT) was significantly increased. After the treatment, the number of patients who had positive reactions to high concentration nasal provocation test (NPT) increased (χ² = 1.93, P = 0.38). During the treatment, all the patients experienced local reactions, and specifically there were four patients got general reactions.</p><p><b>CONCLUSION</b>RIT is safe and effective. It shortened the incremental dose phase remarkably. NPT is a good indicator for diagnosing allergic rhinitis and evaluating the efficacy of the treatment.</p>
Subject(s)
Animals , Humans , Allergens , Allergy and Immunology , Antigens, Dermatophagoides , Allergy and Immunology , Dermatophagoides farinae , Dermatophagoides pteronyssinus , Immunoglobulin G , Blood , Immunotherapy , Methods , Injections, Subcutaneous , Nasal Provocation Tests , Pyroglyphidae , Rhinitis, Allergic , Therapeutics , Sensitivity and Specificity , Skin Tests , Treatment OutcomeABSTRACT
Objective To evaluate the cost-effectiveness and -benefit of the World Bank Loan Project on Schistosomiasis Control in Qianjiang City. Methods According to the national scheme the cost-effectiveness and cost-benefit of the project were analysed. Results After the project was carried out for 9 years, poputation schistosome infections rate decreased by 56.48%; cattle infections rate decreased by 48.08%; snail areas reduced 1224 hm 2(42.76%). Infected snail areas reduced 273 hm 2(17.13%). Snail infections rate decreased by 97.04%. The investment for infections rate decreased by 1% in 100 people was 1384.47 yuan. The investment for infections rate decreased by 1% in 100 head of cattle was 3386.96 yuan. The investment to reduce 1 hm 2 snail ares was 8935.63 yuan. Conclusion For one yuan investment, the benefit was 7.96 yuan and the total of the net benefit was 106784700 yuan in 9 years.